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Drug Treatment for BHP

Drug treatment for BPH

This may be recommended if your symptoms are moderate, but can be beneficial for men with severe symptoms too.

There are two main classes of drug prescribed for BPH.

  • Alpha blockers (alpha %20 blockers)
  • 5-alpha-reductase inhibitors (5-reductase %20 inhibitors)

Alpha blockers:

Alpha blockers work by helping to relax the muscles in the neck of the bladder and in the prostate. This reduces the pressure in the urethra, which subsequently improves urine flow. Symptoms are improved by 29-50% and flow rates by 20-30% within 6 weeks.

Alpha blockers are not a cure for BPH, but help to alleviate symptoms.

Common side effects of Alpha blockers:

  • Tiredness
  • Dizziness
  • Headaches
  • Dry mouth
  • Erectile disorders

Note: Alpha blockers should be avoided in patients with a history of postural hypotension and micturition syncope.

5-alpha-reductase inhibitors

5-alpha-reductase inhibitors work by blocking the conversion of testosterone to another substance: DHT.

DHT is known to have a key role in prostate growth. 5-alpha-reductase inhibitors, unlike alpha blockers, appear to reverse the BPH to some extent, but it can take at least 6 months to be effective.

5-alpha-reductase inhibitors reduce prostate specific antigen (PSA) levels by around 50%, and may reduce the likelihood of developing complications and the requirement for surgery.